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THE CHEMICAL STRUCTURE OF THE AYAHUASCA, is closely related to the chemical structure of some neurotransmitters that our brains naturally secrete. Monoamine oxidase regulates the amount of serotonin and dopamine in our neurotransmitters. DMT -DIMETILTRIPTAMINA-NEUROTRANSMISOR, component considered responsible and propellant of dreams, every night when we sleep our brain from the pineal gland secretes small quantities of DMT is for this reason that we relax and have visions in our dreams.

The first study on the chemical composition of the ayahuasca liana was carried out by a Colombian chemist in 1923, Fischer Cárdenas, who isolated an alkaloid he called telepathy. The name was proposed almost twenty years before by a certain Zerda Bayón. During the twenties of the last century several chemists isolated several alkaloids to which they proposed names like yajeína, yajenina, banisterina and finally, harmina, name that is due to the studies on the Mediterranean plant Peganum harmala (Ruda Siria or harmel) and that showed that all those alkaloids were the same, harmina, an alkaloid well known since the nineteenth century, (Göbel 1841, Fritzche 1847, Fischer 1901).

From all this I summarize that the main alkaloids present in the drink are: Harmina, Harmaline, tetrahydroharmine and DMT -dimethyltryptamine. Harmaline and other related carbolines are inhibitors of MAO, that is, they inhibit the effect of the monoamine oxidase enzymes, which destroy in digestion the other active principle always present in ayahuasca: DMT (dimethyltryptamine). Tryptamines are not psychoactive orally, we only experience effects in combination with MAOIs.

Translating, if we only drank or ate chacruna leaves containing DMT, the enzymes of the stomach would destroy it immediately without experiencing the slightest effect, so thanks to the MAOI present in the vine, which acts as an enhancer, we absorb the DMT. The plant Psychotria viridis, chacruna, contains DMT as a major alkaloid, which also naturally produces our body.

The cause of the psychedelic effects of drinking Ayahuasca is focused on Dimethyltryptamine. The chemical structure of DMT is closely related to the chemical structure of hormones or neurotransmitters, which are naturally secreted by the brain. These physiological agents play a very important role in the biochemistry of mental functioning.

As well as the DMT of the Ayahuasca drink, our own brain secretes a substance that is responsible for night dreams. That is, when a person falls asleep, he meditates, his brain, begins to secrete a chemical substance, equivalent to the DMT of the Ayahuasca, which allows, precisely, the person to dream. The effect of drinking Ayahuasca, then, is approximately like experiencing a dream, but while we are awake, lucid dreams. To feel the effects of Ayahuasca, is like dreaming, but with full awareness of the content of the images and the emotional contents that dye the dream. That is, access to the infinite information that contains our subconscious or spiritual world.

The psychological effects of ayahuasca consumption have been studied by psychiatrists and psychologists for several years. It was determined that the use of psychoactive substances present in some plants can modify the states of consciousness and produce positive therapeutic results in the treatment of diseases such as drug dependence.(Zavala López 1995).

There is a lot of scientific research on the chemistry of ayahuasca and its physiological effects, being able to affirm the following: the toxicity is null the consumption within a controlled context lacks side effects and does not generate addiction, one of its uses being precisely the treatment of dependencies in the detoxification of drug addictions.

Josep Mª Fericgla states: '... after thousands of years of its consumption in the Amazon there is not a single record of misuse, poisoning or accidents as a result of its use. There have been no cases of abuse or addiction to this substance, it is not toxic, it does not generate dependence and there is not a single case of delinquency associated with its consumption.

Although it is in passing, it is worth remembering that our biochemists have highlighted that the human body secretes components (methylated triptamines and beta-carbolines) whose regulation is related at the same time to some mental pathologies and to the states of spiritual elevation, and that It is the same substances that contain the majority of entheogenic products, especially ayahuasca. In most cases, very little is known about how such psychoactive substances act in normal people, although they are known to be related to sleep and onrogenesis. (Fericgla 2001).


The amount of DMT contained in each dose of ayahuasca varies from one town to another, but strangely exceeds 25 mg per dose or 0.53 mg / per 1 ml which is the concentration found in ayahuasca used for modern pharmacology studies. in Spain. A substance that contains dimethyltryptamine (DMT) to be considered a drug must contain at least 2% in the case of Ayahuasca that figure is 0.02%, 100 times lower than the minimum rate required to be labeled as a drug